Spurs will be desperate to hit back when they host Sunderland on Saturday after suffering a shock defeat by Leicester on Wednesday thanks to a late Robert Huth header.
The loss opened up a gap of seven points between Spurs, now fourth, and the league leaders Arsenal and Leicester who are just separated by goal difference.
Pochettino, who again reiterated that striker Harry Kane was not for sale, said: "We missed a great opportunity to establish us on the top and you feel disappointed but you need to carry on and keep working hard.
"It's a very open league. So far anything can happen. All clubs in the top 10 have the possibility to win the league.
"We played well, we deserved more, but in football you need sometimes to have some luck. It wasn't for us last night.
"In the way we played last night it's nothing to worry about for the future.
"We have a quick game on Saturday. It's very important. We must react, play well and take the three points, because we need to keep our position in the table."
Spurs spurned opportunities and Pochettino remains in search of a striker to ease the burden on Kane.
Kane was recently linked with a move to Real Madrid, who on Thursday, along with city rivals Atletico, were hit by a FIFA ban on incoming players in the next two complete transfer windows.
"Harry Kane is not for sale," added Pochettino, who is looking for a player to complement the talents of the England forward.
"We cannot change after one result our plan and our view about our squad. I've explained a lot of times that if we find the right profile and the player that can improve our squad, we work hard for that.
"If we can add some player, we are open to it."
Pochettino would not be drawn on whether he is looking for someone to play alongside Kane or to slot in for the striker to grant a rest.
"The profile is a different profile than we have, that can help us, that sometimes can help with Harry and improve our squad," the Argentine said.
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