The Syrian Observatory for Human Rights said the strike that hit the school in the town of Anjara in the province of Aleppo killed eight children and also injured 20 children and teachers.
The Britain-based monitoring group also reported that three children were killed by rebel rocket fire on a government-held district in Aleppo.
Video posted on social media, which has not been independently verified, shows a tearful young girl who survived the attack saying: "I was supposed to sit my exam today but the plane destroyed my school."
Other pictures show bloodied children covered in dust waiting to be seen in hospital and rescue teams attempting to dig people out of mounds of rubble.
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